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The better treatment efficacy of MBZ-OS was related to the higher drug concentration in plasma, parasites and tissues. It was also shown that the injury of the liver was not significantly altered by taking MBZ-OS compared to the untreated control.
Conclusion These findings demonstrate that MBZ-OS is a promising new formulation of MBZ for treatment of hydatid diseases without showing significantly liver toxicity. Keywords: Mebendazole oily suspension, Cystic echinococcosis, Treatment efficacy, Pharmacokinetics, Histopathology examination, Liver function test Background Cystic echinococcosis (CE) is a life-threatening disease with serious public health and economic concern worldwide.
The proliferation of metacestodes mainly located in liver and lung, leading to the space-occupying lesions.