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The diagnosis DVT presence or absence can (ultimately) be made using repeated leg ultrasound, which requires patient referral and is to some extent burdening and time and money consuming. Hence, it is desirable to predict the presence or absence of DVT without having to refer patients for more cumbersome testing, by rather using easy to obtain predictors from their patient history, physical examination and simple blood assays.

In this article, we use these data to illustrate the described meta-analysis methods for identifying important risk factors.

We assume random effects for factor-outcome associations as the presence of heterogeneity between studies is expected due to differences in locale, setting and time. Detailed information about the included studies and predictors is available in Table S1 and Table S2.